Nogo in nerve regeneration
نویسندگان
چکیده
منابع مشابه
Nogo-C is sufficient to delay nerve regeneration.
Axonal regeneration succeeds in the peripheral but not central nervous system of adult mammals. Peripheral clearance of myelin coupled with selective CNS expression of axon growth inhibitors, such as Nogo, may account for this reparative disparity. To assess the sufficiency of Nogo for limiting axonal regeneration, we generated transgenic mice expressing Nogo-C in peripheral Schwann cells. Nogo...
متن کاملNogo and axon regeneration.
Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo receptor subunit NgR, or blockers of the pos...
متن کاملNogo Domains and a Nogo Receptor:Implications for Axon Regeneration
Two main sites have been considered for the location Diagnosis: You should say of him: “One having a crushed of CNS factors that might inhibit axon regeneration (Figvertebra in his neck; he is unconscious of his two arms, ure 1). One site is the scar that forms at the region of his two legs, he is speechless. An ailment not to be injury. Following CNS injury the central area of necrosis treated...
متن کاملNogo-A expressed in Schwann cells impairs axonal regeneration after peripheral nerve injury
Injured axons in mammalian peripheral nerves often regenerate successfully over long distances, in contrast to axons in the brain and spinal cord (CNS). Neurite growth-inhibitory proteins, including the recently cloned membrane protein Nogo-A, are enriched in the CNS, in particular in myelin. Nogo-A is not detectable in peripheral nerve myelin. Using regulated transgenic expression of Nogo-A in...
متن کاملAxonal regeneration after optic nerve crush in Nogo-A/B/C knockout mice
PURPOSE The axonal regeneration of retinal ganglion cells (RGCs) after optic nerve (ON) crush was investigated both in vivo and in vitro on Nogo-A/B/C knockout mice. METHODS The study used 20 Nogo-A/B/C knockout mice in the experimental group, and 20 C57BL/6 mice in the control group. Partial ON injury was induced by using a specially designed ON clip to pinch the ON 1 mm behind the mouse eye...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature
سال: 2000
ISSN: 0028-0836,1476-4687
DOI: 10.1038/35000309